Prognostic factors in MGUS

Dátum: 10.01.2009 11:40
Vec: Mnohopocetný myelóm

Prognostic factors in monoclonal gammopathy of undetermined significance

Federico Sackmann, Miguel Arturo Pavlovsky, Claudia Corrado, Marco Pizzolato, Mariel Alejandre, Santiago Pavlovsky

Haematologica. 2008 Jan; 93:(1)153-154


A retrospective evaluation of 285 patients with monoclonal gammopathy of undetermined significance was performed to identify variables associated with progression, actuarial progression free survival (PFS) and overall survival (OS). Three variables, level of uninvolved immunoglobulins (HR 4.98, CI95% 2 - 12.4, p=0.0006), monoclonal protein concentration (HR 4.04, CI95% 1.6-10.34, p=0.004), and erythrosedimentation rate (HR 3.94, CI95% 1.33-11.6, p=0.01), showed independent prognostic significance. With a median follow-up of 66 months (range 6-378), PFS and OS at 10 years were 89% and 91% respectively.

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