Prevzaté: Definition, diagnosis and treatment of immune thrombocytopenic purpura
Posted on 30.10.2009 17:17
Topic: Trombocytopenia
Definition, diagnosis and treatment of immune thrombocytopenic purpura
James N. George
Department of Medicine, College of Medicine, Department of Biostatistics and Epidemiology, College of Public Health,
University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
E-mail: james-george@ouhsc.edu. doi:10.3324/haematol.2009.007674
haematologica 2009; 94(6)
In this issue, Arnold and colleagues document by a systematic review of controlled studies that eradication of H. pylori infection increases the platelet count in patients with immune thrombocytopenic purpura (ITP). This observation, together with data from a previous systematic review, requires that we address two questions.
1) What is the role of H. pylori infection in the pathogenesis of ITP?
2) What is the role of eradication of H. pylori infection in the management of ITP?
These questions require a discussion of the definition, diagnosis, and current treatment of ITP. This discussion focuses on adults, as H. pylori infection is rare in children and two current systematic reviews have only identified studies of ITP in adults.
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